1. a congenital neurological condition characterized by the absence or severe underdevelopment of the cerebral gyri (folds) of the brain, resulting in a smooth brain surface.
Usage: medical term; also called lissencephaly in its most severe form

Examples

• Agyria is a rare birth defect that affects brain development and can cause severe developmental delays.
• Infants diagnosed with agyria often experience seizures and intellectual disability.
• The neurologist explained that agyria results from abnormal neuronal migration during fetal development.
• Imaging studies revealed agyria in the patient's frontal and parietal lobes.
• Children with agyria require specialized medical and developmental support throughout their lives.