adverb
- in a manner relating to or involving allosteric regulation, in which a substance binds to a protein at a site other than the active site and affects the protein's function
Usage: technical; biochemistry
Examples
- The enzyme is regulated allosterically by binding of a regulatory molecule to a site distant from the active site.
- Hemoglobin binds oxygen allosterically, meaning that binding at one subunit affects binding at others.
- The drug works allosterically to enhance the receptor's sensitivity without directly activating it.
- Phosphofructokinase is allosterically inhibited by ATP, slowing glycolysis when energy is abundant.
- These proteins interact allosterically to coordinate their catalytic activities.