1. to cause someone to become hostile or angry; to provoke or irritate
2. to act in opposition to; to oppose or resist

Examples

• His rude comments only served to antagonize his coworkers.
• The politician’s speech seemed designed to antagonize his opponents.
• She didn’t want to antagonize her boss by arriving late again.
• The new policy will likely antagonize many customers.
• The rebels continued to antagonize the government forces.
• Try not to antagonize the neighbors with loud music.
• His constant criticism began to antagonize even his closest friends.