noun
- The region of a chromosome where sister chromatids are held together and where spindle fibers attach during cell division.
Usage: biology; genetics
Examples
- The centromere is essential for proper chromosome segregation during mitosis.
- During anaphase, the centromere splits and sister chromatids are pulled to opposite poles of the cell.
- Mutations in centromere proteins can lead to chromosomal instability.
- The centromere contains specialized DNA sequences and proteins that form the kinetochore.
- Scientists study centromeres to understand how chromosomes are accurately distributed to daughter cells.
- Each chromosome has one centromere, which is typically located near the middle of the chromosome.