1. A group of genetic disorders caused by dysfunction of ion channels in cells, leading to abnormal electrical activity and various neurological or muscular symptoms.
Usage: medical/scientific term; plural form; singular is channelopathy; used in neurology, genetics, and cardiology

Examples

• Channelopathies can affect the brain, muscles, and heart, causing seizures, weakness, or arrhythmias.
• Researchers identified a new channelopathy that causes episodic paralysis in affected families.
• Some channelopathies are inherited in an autosomal dominant pattern.
• The patient's symptoms were consistent with a sodium channel channelopathy.
• Genetic testing helped diagnose the channelopathy responsible for the child's seizures.
• Channelopathies represent an important class of neurogenetic disorders.