1. to make someone mentally ill or unstable
Usage: formal
2. to disrupt the normal arrangement or functioning of something
Usage: formal

Examples

• The traumatic experience seemed to derange his mind completely.
• Years of isolation had deranged the hermit’s thinking.
• The storm deranged all our carefully laid plans.
• Don’t let one setback derange your entire schedule.
• The medication can derange normal sleep patterns.
• The accident deranged the delicate machinery.
• Grief had deranged her usual calm demeanor.