1. The outermost sheath of connective tissue that surrounds an entire skeletal muscle.
Usage: anatomy; medical

Examples

• The epimysium provides structural support and protection to the underlying muscle fibers.
• Damage to the epimysium can affect the muscle's ability to contract properly.
• In anatomy class, students learned to identify the epimysium as the outermost layer of muscle tissue.
• The epimysium is continuous with the tendons that attach muscle to bone.
• Inflammation of the epimysium can cause muscle soreness and reduced mobility.