1. the hands and feet; the farthest parts of the limbs from the center of the body
Usage: medical; anatomical
2. the farthest or most remote parts or points of something
3. extreme conditions or situations; the most severe degree of something

Examples

• The cold weather caused numbness in her extremities.
• Frostbite typically affects the extremities first.
• The explorers reached the extremities of the known world.
• The map showed the extremities of the mountain range.
• The war drove people to extremities of desperation.
• He would go to any extremities to protect his family.
• The doctor checked circulation in all four extremities.