noun
- Plural of guanethidine; a class of antihypertensive drugs that lower blood pressure by blocking the release of norepinephrine from nerve endings.
Usage: medical/pharmaceutical; technical term; primarily used in clinical and pharmacological contexts
Examples
- Guanethidines were commonly prescribed for hypertension before newer medications became available.
- The mechanism of action of guanethidines involves inhibition of norepinephrine release.
- Patients taking guanethidines may experience orthostatic hypotension as a side effect.
- Guanethidines are now rarely used due to the development of more selective antihypertensive agents.