1. An amino acid found abundantly in collagen and other proteins, formed by the hydroxylation of proline after protein synthesis.
Usage: biochemistry; technical term; commonly abbreviated as Hyp

Examples

• Hydroxyproline makes up about 10% of the amino acids in collagen.
• The stability of collagen depends partly on its high hydroxyproline content.
• Vitamin C is essential for the hydroxylation of proline to hydroxyproline in collagen synthesis.
• Hydroxyproline residues form hydrogen bonds that stabilize the collagen triple helix.
• Deficiency in vitamin C impairs hydroxyproline formation, leading to weakened connective tissue.