1. superlative form of palsy; most affected by or resembling palsy; most trembling or shaking
Usage: rare; archaic or literary
2. superlative form of palsy (British slang); most contemptible or pathetic
Usage: British slang; informal

Examples

• His palsiest hand could barely hold the pen.
• That was the palsiest excuse I've ever heard.
• The old man's palsiest movements showed his age.
• Of all the attempts, that one was the palsiest.