1. superlative form of prickly; having the most prickles, thorns, or sharp points
2. superlative form of prickly; most easily irritated, sensitive, or touchy in mood or manner
3. superlative form of prickly; most difficult, delicate, or controversial

Examples

• The prickiest part of the cactus is its crown of long spines.
• He was in the prickiest mood after losing the game.
• Immigration is one of the prickiest political issues facing the nation.
• The prickiest roses in the garden require careful handling.
• She became prickiest when anyone questioned her decisions.
• That's the prickiest topic we've discussed all year.