1. most covered with sharp points or thorns
Usage: superlative form of prickly
2. most irritating or difficult to deal with
Usage: superlative form of prickly; figurative

Examples

• The rose bush in the corner was the prickliest of all the plants in the garden.
• This cactus has the prickliest spines I’ve ever seen.
• He becomes the prickliest person when he’s tired.
• That’s the prickliest topic we could discuss at dinner.
• She was in her prickliest mood after the long meeting.
• The prickliest part of the negotiation involved salary discussions.