1. most swollen, inflated, or filled with air; most bloated or enlarged
Usage: superlative form of puffy
2. most soft and light in texture, like a cloud or cushion
Usage: superlative form of puffy

Examples

• Her eyes were the puffiest they had ever been after crying all night.
• The puffiest clouds in the sky looked like cotton balls.
• This is the puffiest jacket I own for winter weather.
• The baker chose the puffiest dinner rolls for the special occasion.
• After the bee sting, his hand became the puffiest it had ever been.
• She picked the puffiest pillow from the selection at the store.